山东省抗糖尿病药物的利用分析：基于2012―2017年的调查数据

来源:用户上传      作者:石文杰 宋燕

　　[摘要]目的分析山东省抗糖尿病药物利用情况，为促进临床合理用药提供依据。方法统计2012―2017年山东省39家不同等级医疗机构药品采购数据，采用回顾性分析方法对抗糖尿病药物品种、采购金额、用药频度（DDDs）和排序比（B/A）进行分析。结果近六年来，抗糖尿病药物采购金额和DDDs整体呈增长趋势。口服降糖药占主导地位，双胍类、磺酰脲类、α-葡萄糖甘酶抑制剂仍是国内三大主流用药，阿卡波糖采购金额最多，二甲双胍DDDs最高，大部分降糖药的B/A接近1，同步性良好。一二、一三、二三级医疗机构采购的平均一致性分别为47.92%、45.34%、61.78%。结论2012―2017年山东省抗糖尿病药物临床应用基本合理，口服降糖药物仍占主导地位，用药结构和日均费用方面基本合理。
　　[关键词]糖尿病;用药频度;用药结构;日均费用
　　[中图分类号]R95 [文献标识码]A [文章编号]2095-0616（2022）02-0113-04
　　Analysis on the application of antidiabetic drugs in Shandong Province：based on survey data from 2012 to 2017
　　SHI Wenjie1，2 SONG Yan1，2
　　l.School of Medical Security，Shandong First Medical University，Shandong Academy of Medical Sciences，Shandong，Jinan 250117，China;2.Shandong Institute of Medicine and Health Information，Shandong，Jinan 250062，China
　　[Abstract] Objective To analyze the application of antidiabetic drugs in Shandong Province，so as to provide a basis for promoting rational application of drugs in clinic. Methods The drug procurement data of 39 medical institutions of different levels in Shandong Province from 2012 to 2017 were collected，and the varieties，procurement amount，defined daily doses （DDDs）and ranking ratio （B/A）of antidiabetic drugs were retrospectively analyzed. Results In the past six years，the procurement amount and DDDs of antidiabetic drugs showed an overall increasing trend. The varieties of antidiabetic drugs were dominated by oral hypoglycemic drugs，and biguanides，sulfonylureas and a-glucosidase inhibitors were still the three main drugs in China. The procurement amount of acarbose was the highest and the medication frequency of metformin ranking the highest，and the B/A of most hypoglycemic drugs was close to 1，with good synchronization. The average consistency of the procurement by the first two，first three and second three levels of medical institutions was 47.92%，45.34% and 61.78%，respectively. Conclusion The application of antidiabetic drugs in clinic in Shandong Province from 2012 to 2017 was generally reasonable，the varieties of antidiabetic drugs were still dominated by oral hypoglycemic drugs，and the medication structure and defined daily cost were generally reasonable.
　　[Key words] Diabetes;Defined daily doses;Medication structure;Defined daily cost
　　S着经济发展、生活节奏的加快，我国糖尿病发病率呈现逐年上升的趋势，患病率已达到10.4%，是糖尿病患者最多的国家，且发病日趋年轻化[1-2]。糖尿病已成为我国重要的公共卫生问题，治疗和控制该病十分重要和紧迫。作为一种慢性病，需要长期服药，药品可负担性与疾病的治疗和控制有着密切的联系[3]。传统抗糖尿病药物有双胍类、α-葡萄糖苷酶抑制剂、磺酰脲类、格列奈类、TZDs及胰岛素和胰岛素类似物，之后又出现了一些新型药物，如DPP-4抑制剂、GLP-1受体激动剂、SGLT-2抑制剂等[4-5]。通过对山东省抗糖尿病药物的使用情况进行分析，为临床合理用药提供依据。

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