基于文献研究的中医药治疗代谢相关脂肪性肝病的用药规律分析

来源:用户上传      作者:刘洁 游运舸

　　[摘要]目的探究以中治疗代谢相关脂肪性肝病的用药规律，为临床治疗代谢相关脂肪性肝病提供参考依据。方法使用计算机检索从2011年1月1日至2021年10月21日在中国知网（CNKI）中收录的中医药治疗代谢相关脂肪性肝病的相关临床研究文献。采用 Excel 表格创建“代谢相关脂肪性肝病”数据库并引入古今医案云平台（V2.3.5），应用该软件系统中的频数统计、聚类分析、关联分析等方式实现资源数据分析，对重要中药的四气、五味、归经与组方规律等进行分析。结果经过遴选共纳入有关文献91篇，去除重复处方后涉及中药处方91首，中药172味，其中使用频率前11位的药物从高到低依次为山楂、丹参、泽泻、茯苓、白术、柴胡、郁金、决明子、甘草、半夏、陈皮。药味多为苦、甘、辛，药性多为微寒、温，使用药材主要归经为脾经和肝经，功效一般包括利水渗湿、清热解毒、润肠通便、消食和胃、行气散瘀等。结论中医药治疗代谢相关脂肪性肝病遵循辨证论治、标本兼顾之则，以肝脾为本，强调气滞、湿浊、痰瘀等病理因素的致病性，予以疏肝理气、利水渗湿、燥湿化痰、活血化瘀等治疗。
　　[关键词]代谢相关脂肪性肝病;非酒精性脂肪性病肝;中医药;文献分析;用药规律
　　[中图分类号] R259 [文献标识码] A [文章编号]2095-0616（2022）09-0040-05
　　Analysis of the medication rules of traditional Chinese medicine in the treatment of metabolic-associated fatty liver disease based on literature research
　　LIU Jie YOU Yunge2
　　1. Department of Spleen， Stomach and Liver Diseases， the Hospital of Hunan University of Traditional Chinese Medicine， Hunan， Changde 415000， China;2. Department of Prevention and Treatment， the Hospital of Hunan University ofTraditional Chinese Medicine， Hunan， Changde 415000， China
　　[Abstract] Objective To study the medication rules of traditional Chinese medicine in the treatment of metabolic- associated fatty liver disease （MAFLD）， and to provide a reference for clinical treatment of MAFLD. Methods The relevant clinical research articles of traditional Chinese medicine in the treatment of MAFLD included in the China National Knowledge Infrastructure （CNKI） from January 1， 2011 to October 21， 2021 were retrieved by using computer. The database of "metabolic-associated fatty liver disease" or "MAFLD" was created using Excel and introduced into the Ancient and Modern Medical Record Cloud Platform （V2.3.5）. The resource data was analyzed by the frequency statistics， cluster analysis， association analysis and other methods in the software system， and the four qi， five flavors and meridian distribution of the important traditional Chinese medicines and the rules of the prescriptions were analyzed. Results After selection， a total of 91 related articles were included. After removing duplicate prescriptions， there were 91 prescriptions of traditional Chinese medicine and 172 flavors of traditional Chinese medicine， in which the top 11 drugs with the highest frequency of use in the order from high to low were as follows： Crataegi Fructus， SalviaeMiltiorrhizae Radix et Rhizoma， AlismatisRhizoma， Poria， AtractylodisMacrocephalaeRhizoma， Bupleuri Radix， Curcumae Radix， Cassiae Semen， Glycyrrhizae Radix et Rhizoma， PinelliaeRhizoma， and CitriReticulataePericarpium. The taste of the medicine is mostly bitter， sweet， and acrid， and the medicinal properties are mostly mildly cold and warm. The medicinal materials used mainly act on the spleen and liver meridians. The efficacy generally includes diuresis and dampness， heat-clearing and detoxification， laxatives， stomach strengthening and digestion，qi promotion and blood stasis dissipation， etc. Conclusion Taking into account the symptoms and cause of disease， focusing on the liver and spleen， and emphasizing the pathogenicity of pathological factors such as qi stagnation， damp turbidity， phlegm stasis， etc.， the traditional Chinese medicine treatment of MAFLD includes liver soothing and qi regulation， diuresis and dampness， dry dampness and phlegm， blood circulation promotion and blood stasis removing and others according to the principles of syndrome differentiation and treatment.

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