降钙素原、C反应蛋白在急性左心衰竭患者肺部感染诊断中的应用效果

来源:用户上传      作者:柳菲 侯栋

　　[摘要]目的探降钙素原（PCT）和 C 反应蛋白（CRP）在急性左心衰竭患者肺部感染诊断中的临床价值。方法选取2019年1月至2020年12月博尔塔拉蒙古自治州人民医院收治的200例急性左心衰竭患者作为研究对象，按照是否合并肺部感染分为两组，每组各100例，分别设为观察组（合并肺部感染）和对照Ⅰ组（无肺部感染），并将同期收取的100名健康志愿者作为对照Ⅱ组，对三组 PCT、CRP 水平进行检测，比较三组受检者检测结果差异及 PCT、CRP 单独及联合检测的诊断价值。结果观察组 PCT、CRP 水平均高于对照Ⅰ组和对照Ⅱ组，差异有统计学意义（ P <0.05）;对照Ⅰ组 PCT、CRP 水平高于对照Ⅱ组，差异有统计学意义（ P <0.05）;PCT、CRP 联合检测诊断急性左心衰竭患者合并肺部感染的敏感度、特异度、准确度明显高于 PCT、CRP 单独检测诊断，差异有统计学意义（P <0.05）;PCT、CRP 联合检测诊断急性左心衰竭患者合并肺部感染的曲线下面积、约登指数、95%CI 均明显高于 PCT、CRP 单独检测诊断，差异有统计学意义（P<0.05）。结论 PCT、CRP 联合检测急性左心衰竭合并肺部感染具有较高的诊断价值，与 PCT、CRP 单独检测比较，其敏感度、特异度及准确度均更高。
　　[关键词]降钙素原; C 反应蛋白;急性左心衰竭;肺部感染;诊断价值
　　[中图分类号] R563.1;R541.6 [文献标识码] A [文章编号]2095-0616（2022）14-0126-04
　　Effects of PCT and CRP in the diagnosis of pulmonary infections in patients with acute left heart failure
　　LIU Fei HOU Dong
　　Department of Cardiovascular Medicine， Bortala Mongolian Autonomous Prefecture People's Hospital， Xinjiang， Bole 833400， China
　　[Abstract] Objective To explore the clinical value of procalcitonin （PCT） and C-reactive protein （CRP） in the diagnosis of pulmonary infections in patients with acute left heart failure. Methods A total of 200 patients with acute left heart failure admitted to the Bortala Mongolian Autonomous Prefecture People's Hospital from January 2019 to December 2020 were selected as study subjects. They were divided into the observation group （n=100， complicated with pulmonary infection） and control group Ⅰ（n=100， without pulmonary infection） according to whether they were complicated with pulmonary infections， and another 100 healthy volunteers in the same period were selected as control group Ⅱ. The levels of PCT and CRP were detected in the three groups， and the differences in the detection results of the three groups and the diagnostic value of PCT and CRP alone and in combination were compared. Results The PCT and CRP levels in the observation group were higher than those in control group Ⅰ and control group Ⅱ ， with statistically significant differences （P <0.05）， and those in control group Ⅰ were higher than those in control group Ⅱ ， with statistically significant differences （P <0.05）. The sensitivity， specificity and accuracy of the combination of PCT and CRP in diagnosing patients with acute left heart failure complicated with pulmonary infections were significantly higher than those of PCT and CRP detection alone， with statistically significant differences （P <0.05）. The area under the curve， Youden index and 95%CI of PCT and CRP combined detection in the diagnosis of acute left heart failure patients with pulmonary infection were significantly higher than those of PCT and CRP detection alone， and the differences were statistically significant （P <0.05）. Conclusion Better diagnostic effect and higher sensitivity， specificity and accuracy can be achieved by the combination of PCT and CRP than PCT and CRP alone in diagnosing acute left heart failure complicated with pulmonary infections.

nlc202208161041

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