基于历史数据的肠癌术后肠功能紊乱方药分析

来源:用户上传      作者:王安琪 王玉婷 李志利 黄楚月 吕政融 樊志敏

　　[摘要]目的归纳总结肠癌术后肠功能紊乱的常用中药模式及配伍规律。方法运用中医传承辅助平台（V2.50）检索筛选数据库获得肠癌术后肠功能紊乱的中药处方，对检索结果进行频次、四气、五味、归经统计，并采用关联规则、系统聚类等方法分析处方的用药规律。结果收录处方102首，涉及中药283味;其中温、平药性及甘、苦药味占比较高，归经以脾、胃、肺、肝经的用药多。挖掘得到高频药物组合28组（频次≥30次）、药物关联规则21条、潜在新处方10首。结论中医药治疗肠癌术后肠功能紊乱以四君子汤为基础，虚、湿、瘀、毒互结，临床还应兼顾肺、肝共治，综合改善症状。
　　[关键词]数据挖掘;结直肠肿瘤;肠功能紊乱;用药规律;中医传承辅助系统
　　[中图分类号] R249; R273[文献标识码] A [文章编号]2095-0616（2022）15-0086-05
　　Historical data-based analysis on prescription drugs for bowel dysfunction after intestinal cancer surgery
　　WANGAnqiWANGYutingLIZhiliHUANGChuyueLVZhengrongFANZhimin
　　Nanjing Hospital ofChinese Medicine Affiliated to Nanjing University ofChinese Medicine， Jiangsu， Nanjing 210000， China
　　[Abstract] Objective To summarize the common Chinese materia medica （CMM） and the compatibility rules for bowel dysfunction after intestinal cancer surgery. Methods The CMM prescriptions for bowel dysfunction after intestinal cancer surgery were retrieved and screened from databases of the traditional Chinese medicine inheritance support system （V2.50）， and the retrieved results were organized by frequency， the four natures and five flavors and meridian tropism of CMMs. In addition， the medication rules of these prescription drugs were analyzed by using association rules and system entropy clustering. Results A total of 102 prescriptions with 283 flavors of CMMs were included， among which warm- and mild-natured， and sweet- and bitter-flavored CMMs accounted for a high proportion， with meridian tropism mostly in spleen， stomach， lung and liver. Besides， 28 groups of high-frequency drug combinations （frequency ≥30 times）， 21 drug association rules， and 10 potential new prescriptions were obtained by data mining. Conclusion The treatment of bowel dysfunction after intestinal cancer surgery with traditional Chinese medicine is based on Sijunzi Decoction， and to target the features of deficiency， dampness， stasis and toxicity intertwining of this disorder， the lung and liver co-treatment should also be taken into account in clinical treatment to improve symptoms comprehensively.
　　[Key words] Data mining; Colorectal cancer; Bowel dysfunction; Medication rules; Traditional Chinese medicine inheritance support system
　　近年沓Π┓⒉÷屎筒∷缆逝噬，手术仍为主要治疗方式，但患者术后常出现肠功能紊乱，具体表现为便秘、泄泻、大便失禁等，严重影响患者生活质量，也造成患者巨大精神负担。现代医学常从前切除综合征入手改善紊乱症状[1]，以对症治疗为主导，但疗效有限[2]。中医药治疗肠癌术后肠功能紊乱以辨证论治为依据，因人制宜，在提升生活质量、减轻患者经济负担等方面卓有成效[3]，但缺乏系统的用药规律整理。中医传承辅助平台将信息资料录入、保存、提取、统计和分析等功能融为一体[4]，数据客观真实，广泛运用于中医药研究中，本研究选用中医传承辅助平台（V2.50）对名老中医治疗肠癌术后肠功能紊乱经验方加以整理总结[5]，指导临床用药选择。

nlc202209151639

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