基于MIMICS建模和SimVascular仿真计算的不同狭窄率颈动脉非牛顿血流动力学分析

来源:用户上传      作者:高铭泽 陈广新 陈晓琴 胡明成 成志国 林强

　　[摘要]目的颈动脉狭窄程度对动脉粥样硬化斑块的形成机制血流动力学因素分析。方法采集颈动脉狭窄患者 CTA 影像数据，应用 MIMICS 软件创建三种颈动脉狭窄模型（0度狭窄、轻度狭窄、重度狭窄），利用3-matic 软件对三种不同狭窄的颈动脉模型进行修复、优化表面网格，利用血流动力学仿真软件SimVascular对三种狭窄率模型进行非牛顿流体数值模拟。结果颈动脉狭窄区域的血流速度分布与狭窄率紧密联系，狭窄区域壁切应力随着狭窄率增高而变大，狭窄区域壁面压力出现负压，颈动脉狭窄部位壁面切应力随狭窄率增高，血流出现涡流、二次流、回流。结论狭窄率与颈动脉血流动力学因素密切相关，狭窄率的大小与粥样硬化斑块的形成、发展密切相关。
　　[关键词]狭窄率;颈动脉;动脉粥样硬化;斑块
　　[中图分类号] R318.11[文献标识码] A [文章编号]2095-0616（2022）15-0046-04
　　Non-Newtonian hemodynamic analysis of carotid with different stenosis rates basedon MIMICS modeling andSimVascular simulation calculation
　　GAOMingze1CHENGuangxin1CHENXiaoqin1HUMingcheng2CHENGZhiguo1 LINQiang2
　　1. College of Medical Imaging， Mudanjiang Medical University， Heilongjiang， Mudanjiang 157011， China;2. Hongqi Hospital Affiliated to Mudanjiang Medical University， Heilongjiang， Mudanjiang 157011， China
　　[Abstract] ObjectiveTo analyze the hemodynamic factors impacting the formation mechanism of atherosclerotic plaques by the degree of carotid stenosis . MethodsCTA image data of patients with carotid stenosis were collected .3 types of carotid stenosis models （0-degree stenosis， mild stenosis and severe stenosis） were created by MIMICS software .3 types of carotid models with different stenosis were repaired and their surface meshes were optimized by 3-matic software . The non-Newtonian fluid numerical simulation of 3 types of stenosis rate models was carried out by the hemodynamic simulation software SimVascular. Results The distribution of blood flow velocity in the carotid stenosis area was closely related to the stenosis rate . The wall shear stress in the narrow area increased with the increase in stenosis rate， and the wall pressure in the narrow area appeared negative pressure . And the wall shear stress in the carotid stenosis area increased with the stenosis rate， resulting in vortex， secondary flow and reflux of blood flow . ConclusionThe stenosis rate is closely related to the hemodynamic factors of carotid， and the size of stenosis rate is closely related to the formation and development of atherosclerotic plaque .
　　[Key words] Stenosis rate; Carotid; Atherosclerosis; Plaque
　　i动脉为颅内组织供血，颈动脉斑块是引起脑卒中的重要原因之一[1]。颈动脉狭窄的形成原因比较复杂，血管内膜损伤、血管壁蛋白纤维作用减弱导致的血管壁硬化、变厚等均促成颈动脉粥样硬化[2]。已有研究证实，血流动力学因素是颈动脉粥样硬化和血栓形成的重要因素[3]。目前，现有的医学检查手段仍无法对体内的血流动力学分布特征进行有效测量。近些年计算流体力学（computational fluid dynamics， CFD）快速发展，将 CFD 技术应用于血流动力学仿真分析可实现颈动脉内的血流动力学分布特征参数，对颈动脉狭窄的发生发展、病理机制研究有重要的意义[4]。本研究基于 MIMICS 软件对个体化 CTA 真实患者数据构建轻中度三种狭窄程度的几何模型、利用 CFD 仿真软件SimVascular进行血流动力学仿真计算，分析不同狭窄程度对颈动脉的血流动力学指标的特征分布规律，并探讨狭窄率大小与颈动脉斑块的形成关系。

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