内皮蛋白C受体在重度子痫前期孕妇胎盘组织和血浆中的表达及意义

来源:用户上传      作者:张佳 刘芳 郑丹

　　[摘要] 目的 探内皮蛋白C受体（ERCR）在重度子痫前期孕妇胎盘组织和血浆中的表达及意义。 方法 选取2017年5月至2020年6月南昌市第一医院接收的70例重度子痫前期孕妇（研究组）和70名健康孕妇（健康组）作为本研究对象，两组进行胎盘组织和血浆ERCR检测，比较两组的血浆游离ERCR水平、胎盘组织结合型ERCR mRNA相对表达量和胎盘组织结合型ERCR蛋白阳性表达率;同时根据重度子痫前期的类型，比较早发型和晚发型孕妇的血浆游离ERCR水平、胎盘组织结合型ERCR mRNA相对表达量和胎盘组织结合型ERCR阳性表达率。 结果 经检测，研究组的血浆游离ERCR水平明显高于健康组，其胎盘组织结合型ERCR mRNA相对表达量明显低于健康组（P<0.001）;同时，研究组的胎盘组织结合型ERCR蛋白阳性表达率（58.57%）明显低于健康组（97.14%）（P<0.001）。在重度子痫前期类型方面，早发型孕妇的血浆游离ERCR水平明显高于晚发型孕妇，其胎盘组织结合型ERCR mRNA相对表达量明显低于晚发型孕妇（P<0.001）;且早发型孕妇胎盘组织结合型ERCR蛋白阳性表达率（32.44%）也低于晚发型孕妇（87.87%）（P<0.001）。 结论 早发型重度子痫前期孕妇胎盘组织和血浆中的ERCR表达明显升高，而晚发型重度子痫前期孕妇胎盘组织和血浆中的ERCR无明显变化，ERCR可作为早发型重度子痫前期的预测指标。
　　[关键词] 重度子痫前期;孕妇;胎盘组织;血浆;内皮蛋白C受体
　　[中图分类号] R714.245 [文献标识码] A [文章编号] 1673-9701（2022）02-0009-04
　　Expression and significance of endothelial protein C receptor in placental tissue and plasma of pregnant women with severe preeclampsia
　　ZHANG Jia LIU Fang ZHENG Dan
　　Department of Gynecology and Obstetrics， Nanchang First Hospital， Nanchang 330000， China
　　[Abstract] Objective To investigate the expression and significance of endothelial protein C receptor （ERCR） in placental tissue and plasma of pregnant women with severe preeclampsia. Methods A total of 70 pregnant women with severe preeclampsia （study group） and 70 healthy pregnant women （healthy group） who were admitted to Nanchang First Hospital from May 2017 to June 2020 were selected as the research objects， and the placental tissue and plasma ERCRs were detected in the two groups. The plasma free ERCR levels， relative expression levels of binding ERCR mRNA and positive expression rates of binding ERCR protein in the placental tissue were compared between the two groups. Meanwhile， according to the type of severe preeclampsia， the levels of plasma free ERCR， the relative expression levels of placental tissue binding ERCR mRNA and the positive expression rates of placental tissue binding ERCR were compared between the early onset and late onset pregnant women. Results The level of free ERCR in plasma in the study group was significantly higher than that in the healthy group， and the relative expression of placental tissue binding ERCR mRNA in the study group was significantly lower than that in the healthy group （P<0.001）. Meanwhile， the positive expression rate of placental tissue binding ERCR protein in the study group was 58.57%，which was significantly lower than that of 97.14% in the healthy group （P<0.001）. For the type of severe preeclampsia， the plasma free ERCR level of early onset women was significantly higher than that of late onset women， and the relative expression level of placental tissue binding ERCR mRNA of early onset women was significantly lower than that of late onset women （P<0.001）. The positive expression rate of placental tissue binding ERCR protein in early onset pregnant women was 32.44%， which was also lower than that of 87.87% in late onset pregnant women （P<0.001）. Conclusion The expression of ERCR in the placental tissue and plasma of pregnant women with early onset severe preeclampsia significantly increase， while the expression of ERCR in the placental tissue and plasma of pregnant women with late onset severe preeclampsia does not significantly change. ERCR can be used as a predictor of early onset severe preeclampsia.
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