基于数据挖掘探讨姜良铎教授治疗肺部结节的用药规律
来源:用户上传
作者:刘涓 郭宙 薛丹
摘 要：目的 利用稻萃诰蚣际跆剿鞴槟山良铎教授治疗肺部结节用药特点及方剂配伍规律。方法 收集2010年1月～2020年7月姜良铎教授治疗肺部结节病的有效病例方剂238首录入数据库，采用R语言及Python语言作为数据挖掘工具，对用药及性味归经等数据进行关联性研究，通过层次聚类挖掘核心处方。结果 筛选处方238首，分析确定药物使用频次、药物之间的关联规则，用药频率>40%的中药有10味，常用的药物关联组合为1个核心药物加2组药物，处方以苦味药为主，以肝经作为主要归经的关联用药规律。聚类得出核心处方为黄芩加葛根汤去甘草加石膏、枳实、枳壳，并常辅以活血化瘀、清热化痰、软坚散结之药。结论 姜良铎教授在肺部结节的治疗过程中，方剂配伍常以理气活血、软坚散结、清热化痰等中药组合为主，重视肝、脾、大肠、心、胃等与肺的关联，喜用辛苦、苦温、甘寒之药。
关键词：肺部结节;方药规律;R语言;关联分析;层次聚类
中图分类号：R249 文献标识码：A 文章编号：1009-8011（2022）-6-000-05
Discussion on Medication Rules of Professor Jiang Liangduo’s Formulas for Pulmonary Nodules Based on Data Mining
LIU Juan1 GUO Zhou2 XUE Dan1*
（1.Prevention and Treatment Center， Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China;
2.Department of Internal Medicine， Changping District Hospital of Integrated Traditional Chinese and Western Medicine， Beijing 102208， China）
Abstract：Objective To analyze Professor Jiang Liangduo’s medication characteristics and prescription compatibility in the treatment of pulmonary nodules. Methods The effective prescriptions of Professor Jiang Liangduo in the treatment of pulmonary sarcoidosis were collected and entered into the database. R language and python language were used as data mining tools to study the correlation between the data of herbsuse， sex， taste and meridian tropism. Results 238 prescriptions were screened， and the frequency of herbs use and the association rules between herbs were analyzed and determined. There were 10 kinds of traditional Chinese medicine with more than 40% frequency in herbs use. The commonly herbs-associated combination consisted of one core herb and two other groups. The main prescription was bitter herbs， and the main channel was liver. Cluster analysis showed that the core prescription was Scutellaria plus Gegen decoction， minus licorice plus gypsum， Fructus aurantii， Fructus aurantii， often with herbs of promoting blood circulation and removing blood stasis， clearing heat and resolving phlegm， softening hard and dispersing knot. Conclusion In the treatment of pulmonary nodules， Professor Jiang Liangduo’s prescriptions are mainly composed of traditional Chinese medicine， such as regulating qi and activating blood circulation， softening hard and dispersing knot， clearing heat and resolving phlegm. Great importance was attached to the relationship between liver， spleen， large intestine， heart， stomach and lung， and likes to use hard， bitter， warm and sweet cold medicines.
nlc202204021134
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