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  • 强化肌力训练辅助阿仑膦酸对原发性骨质疏松症患者骨密度及骨代谢生化指标的影响

强化肌力训练辅助阿仑膦酸对原发性骨质疏松症患者骨密度及骨代谢生化指标的影响

来源:用户上传      作者:王瑛 冯明宣

  [摘要] 目的 探讨强化肌力训练辅助阿仑膦酸治疗原发性骨质疏松症(POP)对骨密度及骨代谢生化指标的影响。方法 选取2018年1月至2020年8月浙江省台州市中心医院骨科门诊治疗的POP患者90例,随机分为干预组和对照组,每组各45例。两组予钙剂和维生素D联合治疗。对照组在此基础上加口服阿仑膦酸钠片70 mg/次,每周1次;干预组在对照组基础上加肌力强化训练,两组均干预12周。观察治前后两组的骨密度及骨代谢生化指标[血清碱性磷酸酶(ALP)]的变化,并比较临床疗效。结果 干预12周后,两组腰椎骨密度值和股骨颈骨密度值较前明显增加(P<0.05或P<0.01),且干预组增加幅度更显著(P<0.05);两组的血清ALP水平较前明显下降(P<0.05或P<0.01),且干预组下降幅度更显著(P<0.05);同时干预组的总有效率(95.56%)优于对照组(82.22%)(χ2=4.050,P<0.05)。结论 强化肌力训练辅助阿仑膦酸治疗POP患者效果肯定,更能增加骨密度,调节骨代谢指标,使骨吸收下降。
  [关键词] 原发性骨质疏松症;强化肌力训练;阿仑膦酸;骨密度;骨代谢
  [中图分类号] R681 [文献标识码] B [文章编号] 1673-9701(2022)13-0066-04
  [Abstract] Objective To explore the effect of intensive muscle training assisted with alendronic acid on bone mineral density and biochemical indexes of bone metabolism in patients with primary osteoporosis (POP). Methods From January 2018 to August 2020, a total of 90 POP patients in orthopedic clinic of Taizhou Central Hospital in Zhejiang Province were selected and randomly divided into the intervention group and the control group, with 45 cases in each group. Both groups of patients were treated with calcium supplementation and vitamin D. On this basis, the control group was given alendronate sodium tablets 70 mg/time, once a week, orally. The intervention group was given intensive muscle training based on the control group. Patients in both groups were intervened for 12 weeks. The changes of bone mineral density and bone metabolism biochemical indexes (serum alkaline phosphatase [ALP]) in the two groups before and after treatment were observed and compared. The clinical efficacy was compared. Results After 12 weeks of intervention, the lumbar spine bone mineral density values and femoral neck bone mineral density values of the intervention group and the control group were much higher than those before (P<0.05 or P<0.01). And the increase in the intervention group was more significant than that in the control group (P<0.05). The serum ALP of patients in the intervention group and the control group levels were significantly lower than the those before (P<0.05 or P<0.01), and the decrease in the intervention group was more significant than that in the control group (P<0.05). The total clinical effective rate of patients in the intervention group (95.56%) was significantly better than that of the control group (82.22%), and the difference between the two groups was statistically significant (χ2=4.050, P<0.05). Conclusion Intensive strength training assisted by alendronic acid for POP patients has a definite effect. It can significantly increase the patient′s bone density, improve the patient′s bone metabolism level, and reduce bone resorption.

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