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四君子汤加减合桂枝茯苓丸治疗子宫肌瘤的临床研究

来源:用户上传      作者:王春红

  摘 要 目的:探讨四君子汤加减联合桂枝茯苓丸对子宫肌瘤患者激素水平、免疫功能及血清糖类抗原125(CA125)、血管内皮生长因子(VEGF)表达的影响。方法:将141例子宫肌瘤患者随机分为对照组(n=70)和观察组(n=71),对照组采用西医常规治疗,观察组在此基础上给以四君子汤加减和桂枝茯苓丸的联合治疗,比较两组临床疗效。结果:观察组总有效率和免疫功能指标高于对照组;激素水平、VEGF以及CA125的表达水平低于对照组(均P<0.05)。结论:四君子汤加减联合桂枝茯苓丸治疗子宫肌瘤可有效改善患者的免疫功能和激素水平,下调CA125和VEGF的表达。
  关键词 四君子汤 桂枝茯苓丸 CA125 免疫功能 激素
  中图分类号:R271.9; R711.74 文献标志码:A 文章编号:1006-1533(2022)09-0023-04
  引用本文 王春红. 四君子汤加减合桂枝茯苓丸治疗子宫肌瘤的临床研究[J]. 上海医药, 2022, 43(9): 23-26.
  Clinical study on Sijunzi decoction combined with Guizhi Fuling pill in the treatment of hysteromyoma
  WANG Chunhong(Department of Hospital-Acquired Infection Control, the Third People’s Hospital of He’nan Province, Zhengzhou 450000, China)
  ABSTRACT Objective: To explore the effect of Sijunzi decoction combined with Guizhi Fuling pill on the hormone level, immune function and the expression level of carbohydrate antigen 125 (CA125) and vascular endothelial growth factor(VEGF) in patients with hysteromyoma. Methods: One hundred and forty-one patients with hysteromyoma were randomly divided into a control group (n=70) and an observation group (n=71). The control group was treated with conventional therapy of western medicine, while the observation group was treated with Sijunzi decoction combined with the Guizhi Fuling pill on the basis of the control group. The clinical efficacy was compared between the two groups. Results: The total effectiveness and the immune function indexes were higher and the hormone level and the expression levels of VEGF and CA125 were lower in the observation group than the control group (all P<0.05). Conclusion: Sijunzi decoction combined with Guizhi Fuling pill has a significant effect on patients with hysteromyoma, and can effectively improve the immune function and hormone level and downregulate the expression levels of CA125 and VEGF.
  KEY WORDS Sijunzi decoction; Guizhi Fuling pill; CA125; immune function; hormone
  子宫肌瘤是一种孕激素分泌过量、妇科炎症等因素导致肌瘤细胞增殖的妇科肿瘤[1],严重影响患者的生活质量和身心健康[2]。调查表明,子宫肌瘤好发于育龄期妇女,在我国的的发病率高达20%以上[3]。手术和药物是子宫肌瘤目前临床常用的治疗方法[4],然而手术治疗对患者机体创伤和内分泌影响较大,且易出现出血、盆腔内脏器粘连、感染等并发症,g后也容易复发,存在一定的局限性[5-6]。对于早期发现的瘤体较小患者,药物治疗是临床首选的方法[7]。在临床上,很多医生[8-9]利用米非司酮等西药以及桂枝茯苓丸等中药治疗子宫肌瘤,患者病情显著改善,子宫肌瘤明显萎缩。但单一的药物治疗效果欠佳[10],往往须要联合用药才能确保疗效[11]。本研究在西药米非司酮治疗的基础上,给以四君子汤方为基础进行加减联合桂枝茯苓丸治疗,旨在分析不同治疗方案的有效性,现将研究结果总结汇报如下。
  1 资料与方法
  1.1 一般资料
  将2018―2020年在河南省直第三人民医院就诊的141例子宫肌瘤患者随机分为对照组(n=70)和观察组(n=71)。对照组:年龄25~55岁,平均(37.18±4.41)岁;病程4~36个月,平均(12.21±4.92)个月;单发52例,多发18例。观察组:年龄26~55岁,平均(37.59±4.57)岁;病程4~36个月,平均(11.91±4.66)个月;单发53例,多发18例。两组患者的年龄、病程、疾病类型等一般资料比较差异无统计学意义(P>0.05),具有可比性。

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