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胺碘酮联合阿托伐他汀治疗冠心病伴心律失常的疗效研究

来源:用户上传      作者:郑华 胡亚兰 张绵 曾东

  摘 要 目的:观察胺碘酮联合阿托伐他汀治疗冠心病(CHD)伴心律失常的疗效。方法:将78例CHD伴心律失常患者随机分为对照组(n=36)和观察组(n=42),两组均接受CHD基础治疗和口服阿托伐他汀,对照组另给予盐酸普罗帕酮片治疗,观察组另给予盐酸胺碘酮片治疗。观察治疗前后两组患者24 h动态心电图相关指标、心功能指标、血液黏度指标,检测血清hs-CRP、Hcy、BNP水平变化;评价两组疗效及不良反应情况。结果:治疗后观察组心电图、心功能、血液黏度指标、hs-CRP、Hcy、BNP、治疗总有效率均优于对照组(均P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论:胺碘酮联合阿托伐他汀治疗CHD伴心律失常可有效改善心功能,降低血液黏度和血清hs-CRP、Hcy、BNP水平。
  关键词 冠心病 心律失常 胺碘酮 阿托伐他汀 疗效
  中图分类号:R972.2; R541.7 文献标志码:B 文章编号:1006-1533(2022)09-0014-04
  引用本文 郑华, 胡亚兰, 张绵, 等. 胺碘酮联合阿托伐他汀治疗冠心病伴心律失常的疗效研究[J]. 上海医药, 2022, 43(9): 14-17; 22.
  Efficacy of amiodarone combined with atorvastatin in the treatment of coronary heart disease with arrhythmia
  ZHENG Hua, HU Yalan, ZHANG Mian, ZENG Dong
  (Department of Critical Care Medicine, the Seventh People’s Hospital of Zhengzhou, Zhengzhou 450016, China)
  ABSTRACT Objective: To observe the efficacy of amiodarone combined with atorvastatin in the treatment of coronary heart disease (CHD) with arrhythmia. Methods: Seventy-eight patients with CHD and arrhythmia were randomly divided into a control group (n=36) and an observation group (n=42). Both groups received basic CHD treatment and oral atorvastatin, and then the control group received propafenone hydrochloride tablets while the observation group received amiodarone hydrochloride tablets. The indexes of 24 h ambulatory electrocardiogram, heart function and blood viscosity and the levels of serum hs-CRP, Hcy, BNP were determined before and after treatment. The efficacy and the incidence of adverse reactions in the two groups were evaluated. Results: After treatment, the indexes of ECG, cardiac function, blood viscosity, the levels of hs-CRP, Hcy, BNP and the overall response rate in observation group were better than those in control group (all P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Amiodarone combined with atorvastatin can effectively improve cardiac function, reduce blood viscosity and serum hs-CRP, Hcy and BNP levels.
  KEY WORDS coronary heart disease; arrhythmia; amiodarone; atorvastatin; curative effect
  冠心病(coronary heart disease, CHD)是因冠状动脉粥样硬化造成管腔狭窄而导致的缺血性心脏病[1]。近年来由于饮食结构变化和生活节奏加快,其初次发病时间呈日益年轻化的趋势[2]。心律失常是导致冠心病患者死亡的高危因素,乐匦穆墒С;颊咛崾驹ず蠹白归不良[3]。目前冠心病伴心律失常的治疗药物有硝酸酯类、降脂药和抗血小板药物等,多种药物联合应用已成为缓解症状的常用方案。他汀类药物调脂效果好,还能减少心脑血管事件的发生,常作为冠心病的辅助治疗药物[4]。胺碘酮作为广谱抗心律失常药物,可扩张外周血管,发挥多种电生理效应[5]。本研究旨在观察胺碘酮联合阿托伐他汀治疗CHD伴心律失常的临床疗效,现报道如下。

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