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丙戊酸钠联合奥氮平治疗青少年双相情感障碍的效果评价

来源:用户上传      作者:李亚坤 刘芬

  摘 要 目的:探丙戊酸钠联合奥氮平治疗青少年双相情感障碍的效果。方法:纳入2019年1月―2021年11月在江西省吉安市第三人民医院心理科接受治疗的60例双相情感障碍患者,采取随机数字表法进行分组,两组各30例。对照组采用丙戊酸钠治疗,首剂量0.2 g/次,2次/d;第四日剂量增加至0.3 g/次,2次/d;第七日增加剂量至0.5 g/次,2次/d。观察组在对照组基础上联合奥氮平治疗,首剂量2.5 mg/晚;第四日剂量增加至5 mg/晚;第七日增加剂量至10 mg/晚。两组均治疗8周。观察韦氏成人智力量表中国修订本(Wechsler adult intelligence scale-Chinese revised,WAIS-RC)评分、韦克斯勒记忆量表(Wechsler memory scale,WMS)评分、抑郁自评量表(self-rating depression scales,SDS)评分、汉密尔顿抑郁量表(Hamilton’s depression scale,HAMD)评分变化情况。结果:干预后,观察组言语智商评分、操作智商评分和智商评分均较干预前明显增长(P<0.05),且均高于对照组(P<0.05);观察组记忆商数评分、长时记忆评分、瞬间记忆评分和短期记忆评分也均较干预前明显增长(P<0.05),且均高于对照组(P<0.05);而SDS评分、HAMD评分较干预前明显下降(P<0.05),且观察组低于对照组(P<0.05)。结论:对于青少年双相情感障碍患者,通过丙戊酸钠联合奥氮平治疗,效果较好,可以改善患者的WAIS-RC评分、WMS评分、SDS评分和HAMD评分。
  关键词 双相情感障碍;青少年;丙戊酸钠;奥氮平;效果
  中图分类号:R749.4 文献标志码:A 文章编号:1006-1533(2022)16-0026-03
  引用本文 李亚坤, 刘芬. 丙戊酸钠联合奥氮平治疗青少年双相情感障碍的效果评价[J]. 上海医药, 2022, 43(16): 26-28, 41.
  Evaluation of effect of sodium valproate combined with olanzapine in the treatment of adolescent bipolar disorder
  LI Yakun, LIU Fen
  (Psychology Department of Jian Third People’s Hospital, Jian, Jiangxi 343000, China)
  ABSTRACT Objective: To investigate the effect of sodium valproate combined with olanzapine in the treatment of adolescent bipolar disorder. Methods: Sixty patients with bipolar disorder who were treated in the Department of Psychology of Jian Third People’s Hospital, Jiangxi Province from January 2019 to November 2021 were included, and divided into two groups with 30 cases in each group by random number table method. The control group was treated with sodium valproate, the first dose was 0.2 g/ time, twice a day, the dose was increased to 0.3 g/time, twice a day on the fourth day; the dose was increased to 0.5 g/time, twice a day on the seventh day. The observation group was treated with olanzapine on the basis of the control group, the first dose was 2.5 mg/night; the dose was increased to 5 mg/night on the fourth day; on the seventh day, the dose was increased to 10 mg/night. Both groups were treated for 8 weeks. The changes of Wechsler adult intelligence scale Chinese revised(WAIS-RC), Wechsler memory scale(WMS), self rating depression scales(SDS) and Hamilton’s depression scale(HAMD) were observed. Results: After intervention, the scores of verbal IQ, operational IQ and IQ in the observation group were significantly higher than those before intervention(P<0.05) and those in the control group(P<0.05); the scores of memory quotient, long-term memory, instant memory and short-term memory in the observation group were also significantly higher than those before intervention(P<0.05) and those in the control group(P<0.05); SDS score and HAMD score in the observation group were significantly lower than those before the intervention(P<0.05), and lower than those in the control group(P<0.05). Conclusion: For adolescent patients with bipolar disorder, sodium valproate combined with olanzapine has a better effect, and can improve the WAIS-RC score, WMS score, SDS score and HAMD score of adolescent patients with bipolar disorder.

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