放射治疗联合奥沙利铂与卡培他滨治疗局部晚期直肠癌的临床疗效

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　　[摘要] 目的 探討放射治疗联合奥沙利铂与卡培他滨治疗局部晚期直肠癌的临床疗效。方法 方便选择2013年5月—2015年2月间该院50例局部晚期直肠癌患者，均无手术指征。随机分组，化疗组采取奥沙利铂与卡培他滨治疗，放化疗组则采取奥沙利铂与卡培他滨+放射治疗。比较两组治疗效率;中位生存的时间;治疗前后患者肿瘤卡氏健康评分、直肠癌生活质量积分;不良作用。 结果 放化疗组有更高的治疗总有效率20（80.00%），化疗组是13（52.00%），（χ2=8.245，P<0.05）。治疗后放化疗组肿瘤卡氏健康评分、直肠癌生活质量积分（81.56±3.22）分、（82.19±4.33）分优于化疗组（70.24±3.11）分、（74.24±4.01）分，（t=5.824、6.054，P<0.05）。放化疗组中位生存的时间（19.11±1.21）个月长于化疗组（14.25±2.11）个月，（t=6.868，P<0.05）;两组的不良作用发生率差异无统计学意义（P>0.05），化疗组的恶心呕吐、白细胞降低、神经毒性、手足综合征分别有20（80.00%）、3（12.00%）、8（32.00%）、5（20.00%），放化疗组分别有21（84.00%）、3（12.00%）、7（28.00%）、4（16.00%），（χ2=0.795、0.000、0.156、0.789，P>0.05）。 结论 奥沙利铂与卡培他滨+放射治疗局部晚期直肠癌可获得较好预后。
　　[关键词] 放射治疗;奥沙利铂;卡培他滨;局部晚期直肠癌;临床疗效
　　[中图分类号] R735          [文献标识码] A          [文章编号] 1674-0742（2019）05（a）-0106-03
　　[Abstract] Objective To investigate the clinical efficacy of radiotherapy combined with oxaliplatin and capecitabine in the treatment of locally advanced rectal cancer. Methods A total of 50 patients with local advanced rectal cancer from May 2013 to February 2015 were convenient selected. There was no indication of operation. Randomly， the chemotherapy group was treated with oxaliplatin combined with capecitabine， and the radiotherapy and chemotherapy group was treated with oxaliplatin and capecitabine plus radiation. The treatment efficiency， the time of median survival， the cancer Karsten health score before and after treatment， the quality of life of rectal cancer; and adverse effects of the two groups was compared. Results The total effective rate of treatment was 20 （80.00%） in the radiotherapy and chemotherapy group， 13 （52.00） in the chemotherapy group（χ2=8.245， P<0.05）. After treatment， the cancer Karscher health score and the rectal cancer quality of life score were （81.56±3.22）points and （82.19±4.33）points， which were better than those of the chemotherapy group （70.24±3.11）points and （74.24±4.01）points， respectively（t=5.824，6.054， P<0.05）. The median survival time of the radiotherapy and chemotherapy group was （19.11±1.21）months， which was longer than that of the chemotherapy group （14.25±2.11）months（t=6.868， P<0.05）. There was no statistically significant difference in the incidence of adverse effects between the two groups（P>0.05）. Cases with nausea and vomiting， decreased white blood cells， neurotoxicity， and hand-foot syndrome in the chemotherapy group were 20 （80.00%）， 3 （12.00%）， 8 （32.00%）， and 5 （20.00%）， respectively. In the radiotherapy and chemotherapy group， the data were 21 （84.00%）， 3 （12.00%）， and 7 （28.00%）， and 4 （16.00%）. （χ2=0.795， 0.000， 0.156， 0.789， P>0.05）. Conclusion Oxaliplatin and capecitabine combined with radiotherapy for local advanced rectal cancer can obtain a better prognosis.
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