糖尿病肾病患者25羟维生素D3与视网膜病变的相关性研究

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　　【摘要】 目的：探究糖尿病腎病25羟维生素D3[25-（OH）D3]与视网膜病变（diabetic retinopathy，DR）相关性。方法：选取本院2017年2月-2018年2月收治的140例糖尿病肾病患者，根据DR情况分为无DR组（n=50）、非增生期DR组（n=47）和增生期DR组（n=43），另选取同期来本院体检的46例健康者为对照组，采用电化学发光法检测所有受试者血清25-（OH）D3水平，探究糖尿病肾病25-（OH）D3与DR的相关性。结果：各组的高密度脂蛋白（high densitylipoprotein cholesterol，HDL-C）、血清总胆固醇（total cholesterol，TC）和低密度脂蛋白（lowdensity lipoprotein cholesterol，LDL-C）比较，差异均无统计学意义（P>0.05）。增生期DR组的25-（OH）D3低于无DR组、非增生期DR组和对照组，差异均有统计学意义（P<0.05），增生期DR组的糖化血清白蛋白（glycated albumin，GA）、血清糖化血红蛋白（glycosylated hemoglobin，HbA1c）均高于无DR组、非增生期DR组和对照组，差异均有统计学意义（P<0.05）。25-（OH）D3与DR之间呈负相关，为中相关性（r=-0.527，P<0.05），GA、HbA1c与DR之间呈正相关，为极弱相关性（r=0.107、0.216，P<0.05）。结论：25-（OH）D3影响着DR的出现及其病理过程，25-（OH）D3水平越低表明DR越重，为控制疾病，应积极检测25-（OH）D3水平，指导临床进行维生素D补充。
　　 【关键词】 视网膜病变; 糖尿病肾病; 25羟维生素D3; 相关性
　　 【Abstract】 Objective：To explore the correlation of 25-hydroxy vitamin D3[25-（OH）D3]with diabetic retinopathy（DR）for diabetic nephropathy.Method：140 diabetic nephropathy patients treated from February 2017 to February 2018 in our hospital were selected and assigned to non-DR group（n=50），non-proliferative DR group（n=47）and proliferative DR group（n=43）according to the situation of DR.46 healthy check-ups were selected as control group.The electrochemiluminescence methods were used to detect 25-（OH）D3 contents.The correlation of 25-（OH）D3 with DR was explored.Result：The high-density lipoprotein cholesterol（HDL-C），total cholesterol（TC）and low-density lipoprotein cholesterol（LDL-C）contents among each groups were not significantly different（P>0.05）.25-（OH）D3 contents in the proliferative DR group was lower than those in the non-DR group，the non-proliferative DR group and control group，the differences were statistically significant（P<0.05）.glycated albumin（GA）and glycosylated hemoglobin（HbA1c）contents in the proliferative DR group were higher than those in the non-DR group，the non-proliferative DR and the control group，the differences were statistically significant（P<0.05）.25-（OH）D3 contents was negatively correlated with DR，and was moderately correlation（r=-0.527，P<0.05）.GA and HbA1c contents were positively correlated with DR，and were extremely weakly correlations（r=0.107，0.216，P<0.05）.Conclusion：The genesis and pathological courses of DR is affected by 25-（OH）D3.The lower 25-（OH）D3 contents indicate the aggravation of DR，in order to control the illness progression，it is necessary to monitor 25-（OH）D3 contents and supplement Vitamin D.
　　 【Key words】 Diabetic retinopathy; Diabetic nephropathy; 25-hydroxy vitamin D; Correlation
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