紫杉醇联合顺铂新辅助化疗方案在局部晚期宫颈癌患者中的应用效果

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　　[摘要]目的 探讨紫杉醇联合顺铂新辅助化疗方案在局部晚期宫颈癌患者中的应用效果。方法 选取2017年9月～2019年7月我院收治的80例局部晚期宫颈癌患者作为研究对象，按照随机数字表法将研究对象分为对照组与试验组，每组各40例。对照组患者仅采用手术治疗，试验组患者在术前采用紫杉醇联合顺铂新辅助化疗方案治疗。比较两组患者的临床治疗效果、淋巴结转移情况和不良反应发生情况。结果 试验组患者的病灶总缓解率（75.00%）高于对照组（52.50%），差异有统计学意义（P<0.05）。试验组患者的宫旁淋巴结转移率、盆腔淋巴结转移率分别为0.00%、2.50%，均低于对照组（10.00%、15.00%），差异有统计学意义（P<0.05）。两组均未出现明显不良反应，两组患者的不良反应总发生率比较，差异无统计学意义（P>0.05）。结论 在局部晚期宫颈癌患者治疗中，术前实施紫杉醇联合顺铂新辅助化疗方案能够提高临床治疗效果，抑制淋巴结转移，且不良反应轻微，更有利于患者病情恢复，值得在临床工作中借鉴。
　　[关键词]局部晚期宫颈癌;新辅助化疗;紫杉醇;顺铂;淋巴结转移;临床疗效;不良反应
　　[Abstract] Objective To explore the application effect of Paclitaxel combined with Cisplatin neoadjuvant chemotherapy in patients with locally advanced cervical cancer. Methods A total of 80 patients with locally advanced cervical cancer admitted to our hospital from September 2017 to July 2019 were selected as the study objects. According to the random number table method， the study objects were divided into control group and experimental group， 40 cases in each group. The control group was only treated by operation， and the experimental group was treated by Paclitaxel combined with Cisplatin neoadjuvant chemotherapy before operation. The clinical treatment effect， lymph node metastasis and incidence of adverse reactions were compared between the two groups of patients. Results The total remission rate of patients in the experimental group （75.00%） was higher than that in the control group （52.50%）， and the difference was statistically significant （P<0.05）. The rates of parauterine lymph node metastasis and pelvic lymph node metastasis in the experimental group were 0.00% and 2.50%， which were lower than those in the control group （10.00% and 15.00%）， and the differences were statistically significant （P<0.05）. There was no significant difference in the total incidence rate of adverse reactions between the two groups （P>0.05）. Conclusion In the treatment of locally advanced cervical cancer， Paclitaxel combined with Cisplatin neoadjuvant chemotherapy before operation can improve the clinical treatment effect， inhibit lymph node metastasis， and the adverse reactions are slight， which is more conducive to the recovery of patients′ condition， and it is worth learning in clinical work.
　　[Key words] Locally advanced cervical cancer; Neoadjuvant chemotherapy; Paclitaxel; Cisplatin; Lymph node metastasis; Clinical efficacy; Adverse reactions
　　宮颈癌是妇科常见恶性肿瘤之一，目前我国发病率较高，且患者呈现年轻化趋势，严重威胁我国女性健康，具体发病与患者体内相关抗癌基因突变有关，同时遗传因素、外界环境刺激等均会增加发病率，临床治疗以手术方式为主，但对于局部晚期宫颈癌患者，存在微小病灶，且术后复发率和转移率较高，预后质量不佳，无法保证手术根除率，因此临床重视找寻一种有效措施以提高手术根除率[1-2]。目前临床尝试在术前给予患者新辅助化疗，杀死微小病灶，抑制肿瘤发展，并达到降级效果，以此提高手术切除率，改善患者预后质量，但化疗方案尚未完全确定，值得进一步探究[3-5]。本研究选取我院收治的80例局部晚期宫颈癌患者作为研究对象，旨在分析紫杉醇联合顺铂新辅助化疗方案治疗局部晚期宫颈癌的临床效果及安全性，现报道如下。
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