海南86例2型糖尿病合并消化系统恶性肿瘤临床特点分析

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　　[摘要] 目的 探討海南地区2型糖尿病合并消化系统恶性肿瘤患者临床特点，提高疾病预防与治疗的认识。 方法 回顾性收集海南医学院第一附属医院2015年1月—2019年6月期间2型糖尿病合并消化系统恶性肿瘤86例和单纯2型糖尿病100例患者的临床资料，分别作为病例组和对照组。结果 ①病例组中，男性73例，女性13例，男性发病率84.88%（73/86），女性发病率15.12%（13/86），男性肿瘤发病率明显高于女性。男性以肝癌高发占32.6%。②两组患者年龄、性别、糖尿病病程、舒张压、糖尿病家族史、TC、TG、LDL、HGB、HbA1c、WBC、RBC、NE、LYM水平差异有统计学意义（P<0.05）。两组患者吸烟、饮酒、高血压病史、收缩压、合并心脑血管疾病、BMI、FPG、HDL、PLT水平差异无统计学意义（P>0.05）。③多因素logistic分析显示：糖尿病家族史、NE与T2DM合并消化系统恶性肿瘤存在显著正相关关系，是T2DM合并消化系统恶性肿瘤的独立危险因素（OR=24.085，3.562，P<0.05）。 结论 2型糖尿病合并消化系统恶性肿瘤患者以男性为主，年龄在43～85岁之间，其中以肝癌高发，依次为结直肠癌、胃癌;糖尿病家族史、NE是T2DM合并恶性肿瘤的独立危险因素。
　　[关键词] 2型糖尿病;消化系统;恶性肿瘤;临床特点;回顾性分析
　　[中图分类号] R587.2          [文献标识码] A          [文章编号] 1672-4062（2020）02（b）-0030-04
　　[Abstract] Objective To explore the clinical characteristics of patients with type 2 diabetes mellitus and digestive system malignancies in Hainan， and to improve the understanding of disease prevention and treatment. Methods The clinical data of 86 patients with type 2 diabetes and digestive system malignant tumors and 100 patients with simple type 2 diabetes were collected retrospectively from January 2015 to June 2019 in the First Affiliated Hospital of Hainan Medical College， which were used as case groups and control group. Results 1.In the case group， there were 73 males and 13 females. The incidence of males was 84.88% （73/86）， the incidence of females was 15.12% （13/86）， and the incidence of male tumors was significantly higher than that of females. The prevalence of liver cancer in men accounted for 32.6%. 2.There were significant differences in age， gender， duration of diabetes， diastolic pressure， family history of diabetes， TC， TG， LDL， HGB， HbA1c， WBC， RBC， NE， and LYM in the two groups（P<0.05）. There were no significant differences in smoking， drinking， history of hypertension， systolic blood pressure， combined cardiovascular and cerebrovascular disease， BMI， FPG， HDL， and PLT levels in the two groups（P>0.05）. 3.Multivariate logistic analysis showed that there was a significant positive correlation between family history of diabetes， NE， and T2DM combined digestive system malignancies， which were independent risk factors for T2DM combined digestive system malignant tumors（OR=24.085，3.562， P<0.05）. Conclusion Type 2 diabetes patients with digestive system malignant tumors are predominantly male， aged between 43 and 85 years old， with liver cancer being the highest incidence， followed by colorectal cancer and gastric cancer; family history of diabetes and NE are independent of T2DM with malignant tumors of risk factors.
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